This week, we speak with Patrick Joyce and Dr. Jeffrey Koury about the challenges and opportunities in the field of decentralized science. We discuss the need for a new economic model in science due to the replication crisis, personal frustrations in academia, and the impact of financial pressures on research integrity. The discussion also covers the role of the ResearchHub and its foundation in incentivizing quality research, the importance of decentralization in scientific publishing, and the evolving landscape of funding and peer review.